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Journal Articles

86.

Zhang, J.; Maschmeyer, T.; Shapiro, B.; Paudel, S. B.; Leclerc, M. C.; Hein, J. E.* “Applying quantum mechanics to deconvolute benchtop 1H NMR reaction data.” React. Chem. Eng., 2024, Advanced Article.

85.

Rauschen, R.; Guy, M.; Hein, J. E.*; Cronin, L.* “Universal chemical programming language for robotic synthesis repeatability.” Nat. Synth, 2024, DOI: 10.1038/s44160-023-00473-6.

84.

Maschmeyer, T.; Conklin, B.; Malig, T. C.; Russell, D. J.; Kurita, K. L.; Hein, J. E.*; Napolitano, J. G.* “A reliable external calibration method for reaction monitoring with benchtop NMR.” Magn. Reson. Chem., 2023, DOI: 10.1002/mrc.5421.

83.

El-khawaldeh, R.; Guy, M. A.; Bork, F.; Taherimakhsousi, N.; Jones, K. N.; Hawkins, J.; Han, L.; Pritchard, R. P.; Cole, B.; Monfette, S.; Hein, J. E.* “Keeping an “eye” on the experiment: Computer vision for real-time monitoring and control.” Chem. Sci., 2023, DOI: 10.1039/D3SC05491H.

82.

El-khawaldeh, R.; Hein, J. E.* “Balancing act: when to flex and when to stay fixed.” Trends Chem., 2023, DOI: 10.1016/j.trechm.2023.10.008.

  • Article awarded Trends in Chemistry issue cover art:
  • Highlighted in “Hot Topic: Automated Synthesis”, which showcases recent publications that report cutting edge research in the rapidly growing field of automated synthesis.

81.

Maschmeyer, T.; Russell, D. J.; Napolitano, J. G.*; Hein, J. E.* “Reaction monitoring via benchtop nuclear magnetic resonance spectroscopy: A practical comparison of on-line stopped-flow and continuous-flow sampling methods.” Magn. Reson. Chem., 2023, DOI: 10.1002/mrc.5395.

80.

Liu, J.; Sato, Y.; Kulkarni, V. K.; Sullivan, A. I.; Zhang, W.; Crudden, C. M.*; Hein, J. E.* “Insights into the synthesis of NHC-stabilized Au nanoclusters through real-time reaction monitoring.” Chem. Sci., 2023, 38(14), p. 10500-10507.

79.

Yang, Fan; Hein, J. E.* “Training a robot arm to estimate the weight of a suspended object.” Device, 2023, 1(1), 100011.

78.

Sato, Y.; Liu, J.; Ndukwe, I. E.; Silva Elipe, M. V.; Griffin, D. J.; Murray, J. I.*; Hein, J. E.* “Liquid/liquid heterogeneous reaction monitoring: Insights into biphasic Suzuki-Miyaura cross-coupling.” Chem Catal., 2023, 3(7), 100687.

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Steven, A.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Barthelme, A.; Richardson, P. F.; Kargbo, R. B.; Phelan, J. P.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2023.

77.

Liu, J.; Hein, J. E.* “Automation, analytics and artificial intelligence for chemical synthesis.” Nat. Synth., 2023, 2, p. 464-466.

76.

Kukor, A. J.; St-Jean, F.; Stumpf, A.; Malig, T. C.; Piechowicz, K. A.; Kurita, K.; Hein, J. E.* “Guided optimization of a crystallization-induced diastereomer transformation to access a key navoximod intermediate.” React. Chem. Eng., 2023, 8(6), p. 1294-1299.

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Steven, A.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Barthelme, A.; Oost, R.; Richardson, P. F.; Kargbo, R. B.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2023.

75.

Deem, M. C.; Hein, J. E.* “A method for converting HPLC peak area from online reaction monitoring to concentration using nonlinear regression.” J. Org. Chem., 2023, 88(2), p. 1292-1297.

  • Top 5 most downloaded/most read content in The Journal of Organic Chemistry in 2023.
  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Steven, A.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Barthelme, A.; Guizzetti, S.; Oost, R.; Richardson, P. F.; Kargbo, R. B.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2023.

74.

Deem, M. C.; Cai, I.; Derasp, J. S.; Prieto, P. L.; Sato, Y.; Liu, J.; Kukor, A. J.; Hein, J. E.* “Best practices for the collection of robust time course reaction profiles for kinetic studies” ACS Catal., 2023, 13(2), p. 1418-1430.

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Steven, A.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Barthelme, A.; Guizzetti, S.; Oost, R.; Richardson, P. F.; Kargbo, R. B.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2023.

73.

Wu, T. C.*; Aguilar-Granda, A.; Hotta, K.; Alasvand Yazdani, S.; Pollice, R.; Vestfrid, J.; Hao, H.; Lavigne, C.; Seifrid, M.; Angello, N.; Bencheikh, F.; Hein, J. E.; Burke, M.; Adachi, C.; Aspuru-Guzik, A.* “A materials acceleration platform for organic laser discovery” Adv. Mater., 2023, 35(6), 2207070.

  • Highlighted in “Hot Topic: Automated Synthesis“, which showcases recent publications that report recent cutting edge research in the rapidly growing field of automated synthesis.
  • Article awarded Advanced Materials issue inside back cover art:

72.

Kukor, A. J.; Hein, J. E.* “Crystallization: A tool for asymmetric synthesis and isolation” Reference Collection in Chemistry, Molecular Sciences and Chemical Engineering, 2022, DOI: 10.1016/b978-0-32-390644-9.00088-3.

71.

Kukor, A. J.; Depner, N.; Cai, I.; Tucker, J.; Culhane, J. C.; Hein, J. E.* “Enantioselective synthesis of (-)-tetrabenazine via continuous crystallization-induced diastereomer transformation” Chem. Sci., 2022, 13(36), p. 10765-10772.

70.

LaPorte, A. J.; Shi, Y.; Hein, J. E.*; Burke, M. D.* “Stereospecific Csp3 Suzuki–Miyaura cross-coupling that evades β-oxygen elimination” ACS Catal., 2022, 12(17), p. 10905-10912.

69.

Gujarati, A.; Wattoo, Z. S.; Aliabadi, M. R.; Clark, S.; Liu, X.; Shiri, P.; Trivedi, A.; Zhu, R.; Hein, J. E.; Seltzer, M. (2022, June 27-30). Arming IDS researchers with a robotic arm dataset [Conference presentation]. The 52nd Annual IEEE/IFIP International Conference on Dependable Systems and Networks, Baltimore, MD, United States.

68.

Deem, M. C.; Derasp, J. S.; Malig, T. C.; Legard, K.; Berlinguette, C. P.; Hein, J. E.* “Ring walking as a regioselectivity control element in Pd-catalyzed C-N cross-coupling” Nat. Commun., 2022, 13, 2869.

  • Highlighted by Nature Communications in the editors’ highlights webpage which showcases recent publications that report recent cutting edge research across the field of catalysis, “Catalysis.”

67.

MacLeod, B. P.; Parlane, F. G. L.; Brown, A. K.; Hein, J. E.; Berlinguette, C. P. “Flexible automation for self-driving laboratories” in Accelerated Materials Discovery: How to Use Artificial Intelligence to Speed Up Development, De Luna, P., Ed.; De Gruyter: Berlin, Germany, 2022, p. 105-122.

66.

Liu, J.; Sato, Y.; Yang, F.; Kukor, A. J.; Hein, J. E.* “An adaptive auto-synthesizer using online PAT feedback to flexibly perform a multistep reaction” Chem. Methods, 2022, 2(8), e202200009.

  • Ranked within the top 10% of papers published by Chem. Methods for 2022.
  • Highlighted by the European Pharmaceutical Review in a news article on their webpage: Balfour, H. Developing an adaptive auto-synthesiser. European Pharmaceutical Review, September 22, 2022. 
  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Steven, A.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Barthelme, A.; Guizzetti, S.; Oost, R.; Richardson, P. F.; Kargbo, R. B.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2023.

65.

Maschmeyer, T.; Yunker, L.; Hein, J. E.* “Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR” React. Chem. Eng., 2022, 7(5), p. 1061-1072.

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Richardson, P. F.; Steven, A.; Kargbo, R. B.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Ramirez, A.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2022.
  • Article awarded Reaction Chemistry & Engineering issue cover art:

64.

Ball-Jones, N. R.; Cobo, A. A.; Armstrong, B. M.; Wigman, B.; Fettinger, J. C; Hein, J. E.*, Franz, A. K.* “Ligand-accelerated catalysis in scandium(III)-catalyzed asymmetric spiroannulation reactions” ACS Catal., 2022, 12(6), p. 3524-3533.

63.

MacLeod, B. P.; Parlane, F. G. L.; Brown, A. K.; Hein, J. E., Berlinguette, C. P.* “Flexible automation accelerates materials discovery.” Nat. Mater., 2021, 21, p. 722-726.

62.

Cleveland, M. E.; Mathieu, Y.; Ribeaucourt, D.; Maon, M.; Mulyk, P.; Hein, J. E.; Lafond, M.; Berrin, J.-G.; Brumer, H.*  “A survey of substrate specificity among Auxiliary Activity Family 5 copper radical oxidases.” Cell. Mol. Life. Sci., 2021, 78, p. 8187–8208.

61.

Christensen, M.; Yunker, L. P. E.; Shiri, P.; Zepel, T.; Prieto, P. L.; Grunert, S.; Bork, F.; Hein, J. E.*  “Automation isn’t automatic.” Chem. Sci., 2021, 12(47), p. 15473-15490.

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Richardson, P. F.; Steven, A.; Kargbo, R. B.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Ramirez, A.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2022, 26(1), p. 1-9.

60.

Kukor, A. J.; Guy, M. A.; Hawkins, J. M.; Hein, J. E.*  “A robust new tool for online solution-phase sampling of crystallizations.” React. Chem. & Eng., 2021, 6(11), p. 2042-2049.

59.

Howard, S. Y.; Di Maso, M. J.; Shimabukuro, K.; Burlow, N. P.; Tan, D. Q.; Fettinger, J. C.; Malig, T.; Hein, J. E.; Shaw, J. T.*  “Mechanistic investigation of Castagnoli-Cushman multicomponent reactions leading to a three-component synthesis of dihydroisoquinolones.” J. Org. Chem., 2021, 86(17), p. 11599–11607.

58.

Häse, F.; Aldeghi, M.; Hickman, R. J.; Roch, L. M.; Christensen, M.; Liles, E.; Hein, J. E.; Aspuru-Guzik, A.* “Olympus: A benchmarking framework for noisy optimization and experiment planning.” Mach. Learn.: Sci. Technol., 2021, 2(3), 035021.

57.

Sato, Y.; Liu, J.; Kukor, A. J.; Culhane, J. C.; Tucker, J. L.; Kucera, D. J.; Cochran, B. M.; Hein, J. E.* “Real-time monitoring of solid-liquid slurries: Optimized synthesis of tetrabenazine.” J. Org. Chem., 2021, 86(20), p. 14069-14078 .

  • Highlighted by Organic Process Research & Development in a Highlights from the Literature piece: Richardson, P. F.; Steven, A.; Kargbo, R. B.; Mateos, C.; Zlota, A. A.; Nawrat, C. C.; Phelan, J. P.; Knight, J.* “Some Items of Interest to Process R&D Chemists and Engineers.” Org. Process Res. Dev., 2021, 25(11), p. 2381-2389.

56.

Cleveland, M.; Lafond, M.; Xia, F. R.; Chung, R.; Mulyk, P.; Hein, J. E.; Brumer, H.* “Two Fusarium copper radical oxidases with high activity on aryl alcohols.” Biotechnol. Biofuels., 2021, 14, 138.

55.

Christensen, M.; Yunker, L. P. E.; Adedeji, F.; Roch, L. M.; Gensch, T.; dos Passos Gomes, G.; Zepel, T.; Sigman, M. S.*; Aspuru-Guzik, A.*; Hein, J. E.* “Data-science driven autonomous process optimization.” Commun. Chem., 2021, 4, 112.

54.

Shiri, P.; Lai, V.; Zepel, T.; Griffin, D.; Reifman, J.; Clark, S.; Grunert, S.; Yunker, L. P. E.; Steiner, S.; Situ, H.; Prieto, P. L.; Hein, J. E.* “Automated solubility screening platform using computer vision.” iScience, 2021, 24(3), 102176. 

53.

Hein, J. E.* “Machine learning made easy for optimizing chemical reactions.” Nature, 2021, 590(7844), p. 40-41.

 

52.

Yang, F.; Lai, V.; Legard, K.; Kozdras, S.; Prieto, P. L.; Grunert, S.; Hein, J. E.* “Augmented titration setup for future teaching laboratories.” J. Chem. Educ., 2021, 98(3), p. 876-881.

  • Article awarded Journal of Chemical Education issue cover art:

51.

Baalbaki, H. A.; Roshandel, H.; Hein, J. E.*; Mehrkhodavandi, P.* “Conversion of dilute CO2 to cyclic carbonates at sub-atmospheric pressures by a simple indium catalyst.” Catal Sci. Technol., 2021, 11(6), p. 2119-2129 .

 

50.

Shi, Y; Prieto, P. L.; Zepel, T.; Grunert, S.; Hein, J. E.* “Automated experimentation powers data science in chemistry.” Acc. Chem. Res., 2021, 54(3), p. 546-555.

  • Article awarded Accounts of Chemical Research, Special Issue: Data Science Meets Chemistry cover art:

 

49.

Maschmeyer, T.; Prieto, P. L.; Grunert, S.; Hein, J. E.*  “Exploration of continuous‐flow benchtop NMR acquisition parameters and considerations for reaction monitoring.” Magn. Reson. Chem., 2020, 58(12), p. 1234-1248.

 

48.

Malig, T. C.; Yunker, L. P. E.; Steiner, S.; Hein, J. E.* “Online high-performance liquid chromatography (HPLC) analysis of Buchwald-Hartwig aminations from within an inert environment.” ACS Cat., 2020, 10(22), p. 13236-13244.

47.

Foth, P. J.; Malig, T. C.; Yu, H.; Bolduc, T. G.; Hein, J. E.*; Sammis, G. M.* “Halide-accelerated acyl fluoride formation using sulfuryl fluoride.” Org. Lett., 2020, 22(16), p. 6682-6686.

 

46.

Zepel, T.; Lai, V.; Yunker, L. P. E.; Hein, J. E.* “Automated liquid-level monitoring and control using computer vision.” ChemRxiv, 2020, DOI: 10.26434/CHEMRXIV.12798143.V1.

 

45.

Malig, T. C.; Tan, Y.; Wisniewski, S. R.; Higman, C. S.; Carrasquillo-Flores, R.; Ortiz, A.; Purdum, G. E.; Kolotuchin, S.; Hein, J. E.* “Development of a telescoped synthesis of 4-(1h)-cyanoimidazole core accelerated by orthogonal reaction monitoring.” React. Chem. & Eng., 2020, 5(8), p.1421-1428.

 

44.

MacLeod, B. P.; Parlane, F. G. L.; Morrissey, T. D.; Häse, F.; Roch, L.; Dettelbach, K. E.; Moreira, R.; Yunker, L. P. E.; Rooney, M. B.; Deeth, J. R.; Lai, V.; Ng, G. J.; Situ, H.; Zhang, R. H.; Aspuru-Guzik, A.*; Hein, J. E.*; Berlinguette, C. P.* “Self-driving laboratory for accelerated discovery of thin-film materials.” Sci. Adv., 2020, 6(20), eaaz8867.

43.

Roch, L. M.*; Häse, F.; Kreisbeck, C.; Tamayo-Mendoza, T.; Yunker, L. P. E.; Hein, J. E.; Aspuru-Guzik, A. “ChemOS: An orchestration software to democratize autonomous discovery.” PLoS ONE, 2020, 15(4), e0229862.

42.

Forget, S. M.; Xia, F.; Hein, J. E.*; Brumer, H.* “Determination of biocatalytic parameters of a copper radical oxidase using real-time reaction progress monitoring.” Org. Biomol. Chem., 2020, 18(11), p. 2076-2084.

41.

Daponte, J. A.; Guo, Y.; Ruck, R. T.; Hein, J. E.* “Using an automated monitoring platform for investigations of biphasic reactions.” ACS Catal., 2019, 9(12), p. 11484–11491.

40.

Chung, R.; Hein, J. E.* “Automated solubility and crystallization analysis of non-UV active compounds: integration of evaporative light scattering detection (ELSD) and robotic sampling.” React. Chem. & Eng., 2019, 4(9), p.1674-1681.

39.

Christensen, M.*; Adedeji, F.; Grosser, S.; Zawatzky, K.; Ji, Y.; Liu, J.; Jurica, J. A.; Naber, J. R.; Hein, J. E.* “Development of an automated kinetic profiling system with online HPLC for reaction optimization.” React. Chem. & Eng., 2019, 4(9), p.1555-1558

38.

Jain, N.; Hein, J. E.*; Ciufolini, M. A.* “Oxidative cyclization of naphtholic sulfonamides mediated by a chiral hypervalent iodine reagent: Asymmetric synthesis versus resolution.” Synlett., 2019, 30(10), p. 1222-1227

37.

Epifanov, M.; Foth, P. J.; Gu ,F.; Barrillon, C.; Kanani, S. S.; Higman, C. S.; Hein, J. E.; Sammis, G. M.* “One-pot 1,1-dihydrofluoroalkylation of amines using sulfuryl fluoride.” J. Am. Chem. Soc., 2018, 140(48), p. 16464-16468.

36.

Chung, R.; Vo, A.; Fokin, V. V.*; Hein, J. E.* “Catalyst activation, chemoselectivity, and reaction rate controlled by the counterion in the cu(I)-catalyzed cycloaddition between azide and terminal or 1-iodoalkynes.” ACS Catal., 2018, 8(9), p. 7889–7897.

35.

Malig, T. C.; Yu, D.; Hein, J. E.* “A revised mechanism for the Kinugasa reaction.” J. Am. Chem. Soc., 2018, 140(29), p. 9167–9173.

34.

Roch, L. M.; Häse, F.; Kreisbeck, C.; Tamayo-Mendoza, T.; Yunker, L. P. E.; Hein, J. E.; Aspuru-Guzik, A.* “ChemOS: Orchestrating autonomous experimentation.” Sci. Robot., 2018, 3(19).

33.

Burford, R. J.; Castro, L.; Maron, L.*; Hein, J. E.*; Fryzuk, M. D.* “Dinitrogen functionalization at a ditantalum center. Balancing N2 displacement and N2 functionalization in the reaction of coordinated N2 and CS2.” Dalton Trans., 2018, 47(24), p. 7983-7991.

32.

Das, U. K.; Higman, C. S.; Gabidullin, B.; Hein, J. E.*; Baker, R. T.* “Efficient and selective iron-complex-catalyzed hydroboration of aldehydes.” ACS Catal., 2018, 8(2), p. 1076–1081.

31.

Phung, C.; Tantillo, D. J.*; Hein, J. E.*; Pinhas, A. R.* “The mechanism of the reaction between an aziridine and carbon dioxide with no added catalyst.” J. Phys. Org. Chem., 2018, 31(1), e3735.

30.

Wilkerson-Hill, S. M.; Yu, D.; Painter, P. P.; Fisher, E. L.; Tantillo, D. J.*; Sarpong, R.*; Hein, J. E.* “Mechanism of a no-metal-added heterocycloisomerization of alkynylcyclopropylhydrazones: Synthesis of cycloheptane-fused aminopyrroles facilitated by copper salts at trace loadings.” J. Am. Chem. Soc., 2017, 139(30), p. 10569 – 10577.

29.

Higman, C. S.; Situ, H.; Blacklin, P.; Hein, J. E.* “Hands-on data analysis: Using 3D printing to visualize reaction progress surfaces.” J. Chem. Ed., 2017, 94(9), p. 1367 – 1371.

28.

Torabifard, H.; Reed, L.; Berry, M. T.; Hein, J. E.; Menke, E.; Cisneros, G. A.* “Computational and experimental characterization of a pyrrolidinium-based ionic liquid for electrolyte applications.” J. Chem. Phys., 2017, 147(16), 161731.

27.

Soley, J.; Chiu, E.; Chung, R.; Green, J.; Hein, J. E.; Taylor, S. D.* “Synthesis of β-ketosulfonamides derived from amino acids and their conversion to β-keto-α,α-difluorosulfonamides via electrophilic fluorination.” J. Org. Chem., 2017, 82(20), p. 11157 – 11165.

26.

Diemoz, K. M.; Hein, J. E.; Wilson, S. O.; Fettinger, J. C.; Franz, A. K.* “Reaction progress kinetics analysis of 1,3-disiloxanediols as hydrogen-bonding catalysts.” J. Org. Chem., 2017, 82(13), p. 6738 – 6747.

25.

Lamb, K. N.; Squitieri, R. A.; Chintala, S. R.; Kwong, A. J.; Balmond, E. I.; Soldi, C.; Dmytrenko, O.; Reis, M. C.; Chung, R.; Addison, J. B.; Fettinger, J. C.; Hein, J. E.; Tantillo, D. J.; Fox, J. M.*; Shaw, J. T.* “Synthesis of benzodihydrofurans by asymmetric C-H insertion reactions of donor/donor rhodium carbenes.” Chem. Eur. J., 2017, 23(49), p. 11843 – 11855.

24.

Chung, R.; Vo, A.; Hein, J. E.* “Copper-catalyzed hydrogen/iodine exchange in terminal and 1-iodoalkynes.” ACS Catal., 2017, 7(4), p. 2505 – 2510.

23.

Weatherly, C.; Alderson, J. M.; Berry, J. F.*; Hein, J. E.*; Schomaker, J. M.* “Catalyst-controlled nitrene transfer by tuning metal:ligand ratios: Insight into the mechanisms of chemoselectivity.” Organometallics, 2017, 36(8), p. 1649 – 1661.

22.

Malig, T. C.; Koenig, J. D. B.; Situ, H.; Chehal, N. K.; Hultin, P. G.; Hein, J. E.* “Real-time HPLC-MS reaction progress monitoring using an automated analytical platform.” React. Chem. Eng., 2017, 2(3), p. 309 –  314.

21.

Chung, R.; Hein, J. E.* “The more, the better: Simultaneous in situ reaction monitoring provides rapid mechanistic and kinetic insight.” Top. Catal., 2017, 60(8), p. 594 –  608.

20.

Rougeot, C.; Situ, H.; Cao, B. H.; Vlachos, V.; Hein, J. E.* “Automated reaction progress monitoring of heterogeneous reactions: Crystallization-induced stereoselectivity in amine-catalyzed aldol reactions.” React. Chem. Eng., 2017, 2(2), p. 226 – 231.

19.

Otero-de-la-Roza, A.; Hein, J. E.*; Johnson, E. R.*: “Reevaluating the stability and prevalence of conglomerates: Implications for preferential crystallization.” Cryst. Growth Des., 2016, 16(10), p. 6055 – 6059.

18.

Squitieri, R. A.; Shearn-Nance, G. P.; Hein, J. E.; Shaw, J. T.*: “Synthesis of esters by in situ formation and trapping of diazoalkanes.” J. Org. Chem., 2016, 81(13), p. 5278 – 5284.

17.

Abel Jr., G. R.; Calabrese, Z. A.; Ayco, J.; Hein, J. E.*; Ye, T.*: “Measuring and suppressing the oxidative damage to DNA during cu(I)-catalyzed azide-alkyne cycloaddition.” Bioconjug. Chem., 2016, 27(3), p. 698 – 704.

16.

Rougeot, C.; Hein, J. E.*: “Application of continuous preferential crystallization to efficiently access enantiopure chemicals.” Org. Proc. Res. Dev., 2015, 19(12), p. 1809 – 1819.

15.

Rodarte, A.L.; Cisnero, F. Hein, J. E.*; Ghosh, S.*; Hirst, L.*: “Quantum dot/liquid crystal nanocomposites in photonic devices.” Photonics, 2015, 2(3), p. 855 – 864.

14.

Chung, R.; Yu, D.; Thai, V. T.; Jones, A. F.; Veits, G. K.; Read de Alaniz, J.; Hein, J. E.*: “Tandem reaction progress analysis as a means of dissecting catalytic reactions: Application to the Aza-Piancatelli rearrangement.” ACS Catal., 2015, 5(8), p. 4579 – 4585.

13.

Veits, G, K; Wenz, D. R.; Palmer, L. I.; Hein, J. E.; Read de Alaniz, J.*: “Cascade rearrangement of furylcarbinols with hydroxylamines: Practical access to densely functionalized cyclopentane derivatives.” Org. Biomol. Chem., 2015, 13(31), p. 8465 – 8469.

12.

Price, I.K.; Rougeot, C.; Hein, J. E.*: “Crystal structure of racemic 5,7-diphenyl-4,7-dihydrotetrazolo-[1,5a] pyrimidine.” Acta Cryst., 2015, 71(3), p. 192.

11.

Price, I.K.; Rougeot, C.; Hein, J. E.*: “Crystal structure of (S)-5,7-diphenyl-4,7-dihydrotetrazolo-[1,5a] pyrimidine.” Acta Cryst., 2015, 71(4), p. 220-221.

10.

Rodarte, A.L.; Cao, B. H.; Panesar, H.; Pandolfi, R.J.; Quint, M.; Edwards, L.; Ghosh, S.; Hein, J. E.*; Hirst, L.S.*: “Self-assembled nanoparticle micro-shells templated by liquid crystal sorting.” Soft Matter, 2015, 11(9), p. 1701 – 1707.

9.

Berry, M. T.; Casterjon, D.; Hein, J. E*.: “Oxidative esterification of aldehydes using mesoionic 1,2,3-triazolyl carbene organocatalysts.” Org. Lett., 2014, 16(14), p. 3676 – 3679.

8.

Abel Jr., G. R.; Cao, B. H.; Hein, J. E.; Ye, T.* “Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry.” Chem. Commun., 2014, 50(60), p. 8131 – 8133.

7.

Otero-de-la-Roza, A.; Cao, B. H.; Price, I. K.; Hein, J. E.; Johnson, E. R.* “Predicting the relative solubilities of racemic and enantiopure crystals by density-functional theory.” Angew. Chem. Int. Ed., 2014, 53(30), p. 7879 – 7882.

6.

Rodarte, A. L.; Nuno, Z. S.; Cao, B. H.; Pandolfi, R. J.; Quint, M. T.; Ghosh, S.*; Hein, J. E.*; Hirst, L. S.* “Tuning quantum-dot organization in liquid crystals for robust photonic applications.” Chemphyschem, 2014, 15(7), p. 1413 – 1421.

5.

Yu, D.; Thai, V. T.; Palmer, L. I.; Veits, G. K.; Cook, J. E.; Read de Alaniz, J.; Hein, J. E.* “Importance of off-cycle species in the acid-catalyzed Aza-Piancatelli rearrangement.” J. Org. Chem., 2013, 78(24), p. 12784 – 12789.

4.

Hein, J. E.*; Cao, B. H.; van der Meijden, M.; Leeman, M.; Kellogg, R. M.* “Resolution of omeprazole using coupled preferential crystallization: Efficient separation of a nonracemizable conglomerate salt under near-equilibrium conditions.” Org. Process Res. Dev., 2013, 17(6), p. 946 – 950.

3.

Burton, A. S.*; Elsila, J. E.; Hein, J. E.; Galvin, D. P.; Dworkin, J. P. “Extraterrestrial amino acids identified in metal-rich CH and CB carbonaceous chondrites from Antarctica.” Meteorit. Planet. Sci., 2013, 48(3), p. 390 – 402.

2.

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